Replicability and Robustness of Genome-Wide-Association Studies for Behavioral Traits

De Neve, Jan-Emmanuel, UNSPECIFIED, Rietveld, Cornelius A. and Conley, Dalton (2014) Replicability and Robustness of Genome-Wide-Association Studies for Behavioral Traits. Psychological Science, 25 (11). pp. 1975-1986.

Abstract

A recent genome-wide-association study of educational attainment identified three single-nucleotide polymorphisms (SNPs) whose associations, despite their small effect sizes (each R2 ≈ 0.02%), reached genome-wide significance (p <5 × 10−8) in a large discovery sample and were replicated in an independent sample (p < .05). The study also reported associations between educational attainment and indices of SNPs called “polygenic scores.” In three studies, we evaluated the robustness of these findings. Study 1 showed that the associations with all three SNPs were replicated in another large (N = 34,428) independent sample. We also found that the scores remained predictive (R2 ≈ 2%) in regressions with stringent controls for stratification (Study 2) and in new within-family analyses (Study 3). Our results show that large and therefore well-powered genome-wide-association studies can identify replicable genetic associations with behavioural traits. The small effect sizes of individual SNPs are likely to be a major contributing factor explaining the striking contrast between our results and the disappointing replication record of most candidate-gene studies.

Item Type: Article
Keywords: behavior genetics, educational attainment, individual differences, genome-wide association study, population stratification
Subject(s): Strategy; Entrepreneurship & Global business
Date Deposited: 11 Aug 2015 11:35
Last Modified: 13 Jul 2017 12:22
Funders: N/A
URI: http://eureka.sbs.ox.ac.uk/id/eprint/5471

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