Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: evidence from a US nationally representative sample

De Neve, Jan-Emmanuel (2011) Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: evidence from a US nationally representative sample. Journal of Human Genetics, 56. pp. 456-459.

Abstract

Variation in the promotor region of the serotonin transporter gene (5-HTTLPR) is a promising candidate for better understanding individual heterogeneity in subjective well-being or happiness, as measured by life satisfaction. This functional polymorphism has previously been associated with mental health and selective processing of positive and negative emotional stimuli. A case–control association study on a representative sample of Americans (N¼2574) finds that individuals with the transcriptionally more efficient version of the serotonin transporter gene, report significantly higher levels of life satisfaction (P¼0.01). This new finding may help explain the important genetic component of the individual baseline levels of happiness.

Item Type: Article
Keywords: 5-HTTLPR; happiness; life satisfaction; population genetics; serotonin transporter; subjective well-being
Subject(s): Strategy; Entrepreneurship & Global business
Centre: Faculty of Strategy, Entrepreneurship and International Business
Date Deposited: 11 Aug 2015 11:40
Last Modified: 23 Oct 2015 14:08
Funders: N/A
URI: http://eureka.sbs.ox.ac.uk/id/eprint/5473

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