Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

Okbay, Aysu, Baselmans, Bart ML, De Neve, Jan-Emmanuel and Turley, Patrick, et al (2016) Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses. Nature Genetics, 48. pp. 624-633.

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Abstract

We conducted genome-wide association studies of three phenotypes: subjective well-being (N = 298,420), depressive symptoms (N = 161,460), and neuroticism (N = 170,910). We identified three variants associated with subjective well-being, two with depressive symptoms, and eleven with neuroticism, including two inversion polymorphisms. The twodepressive symptoms loci replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|p̂| ≈ 0.8) strengthen the overall credibility of the findings, and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are strongly enriched for association.

Item Type: Article
Keywords: Health care
Subject(s): Health care
Date Deposited: 12 Apr 2016 14:19
Date of author-version deposit: 6 April 2016
Last Modified: 24 Sep 2016 02:38
Funders: N/A
URI: http://eureka.sbs.ox.ac.uk/id/eprint/6131

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