Investigating Voice as a Biomarker for leucine-rich repeat kinase 2-Associated Parkinson’s Disease

Arora, Siddharth, Visanji, Naomi P., Mestre, Tiago A., Tsanas, Athanasios, AlDakheel, Amaal, Connolly, Barbara S., Gasca-Salas, Carmen, Kern, Drew S., Jain, Jennifer, Slow, Elizabeth J., Faust-Socher, Achinoam, Lang, Anthony E., Little, Max A. and Marras, Connie Investigating Voice as a Biomarker for leucine-rich repeat kinase 2-Associated Parkinson’s Disease. Journal of Parkinson's Disease, forthcoming, 8 (4). pp. 503-510. (Accepted)

Abstract

We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations (‘aaah’ sounds) were recorded from 7 individuals with LRRK2-associated Parkinson’s disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts.

Item Type: Article
Keywords: LRRK2 mutation; Parkinson’s disease; biomarker; voice; management science
Subject(s): Management science
Date Deposited: 22 Oct 2018 10:47
Last Modified: 22 Oct 2018 10:47
Funders: N/A
URI: http://eureka.sbs.ox.ac.uk/id/eprint/7022

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